Online Oral-Systemic References
&
Antimicrobial Laser-assisted Periodontal Tissue Therapy
Compiled by Dr. Lee Ostler
The Center for Dental Health
1518 Jadwin Ave , Richland, WA 99354
www.makemesmile.info
General Interest - Misc
Periodontal Disease
- Causes of Periodontal Disease: http://www.perio.org/consumer/2a.html
- Cementum and Periodontal Wound Healing and Regeneration http://crobm.iadrjournals.org/cgi/content/abstract/13/6/474
- Dental disease and risk of coronary heart disease and mortality. DeStefano F, Anda RF et al, Brit Med J 306:688-691, 1993, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8471920&dopt=Abstract
- Early Carotid Atherosclerosis in Subjects With Periodontal Diseases http://stroke.ahajournals.org/cgi/content/full/36/6/1195
- Effect of treating periodontitis on C-reactive protein levels http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12475397&dopt=Abstract
- Elevation of Systemic Markers Related to Cardiovascular Diseases in the Peripheral Blood of Periodontitis Patients. J Periodontology 2000 Oct; 71(10):1528-34. http://www.joponline.org/doi/abs/10.1902/jop.2000.71.10.1528
- Molecular Pathogenicity of the Oral Opportunistic Pathogen Actinobacillus Actinomycetemcomitans http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.micro.57.030502.090908
- Periodontal Disease and Risk of Cerebrovascular Disease. Wu T et al, Arch Intern Med. 2000; 160:2749-2755. http://archinte.ama-assn.org/cgi/content/abstract/160/18/2749
- Periodontal disease and systemic health--what you and your patients need to know. http://www.cda.org/cda_member/pubs/journal/jour0402/systemic.html ; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12005375&dopt=Abstract
- Periodontal Infections Contribute to Elevated Systemic C-Reactive Protein Level. Noack et al, J Periodontol. 2001 Sep;72(9):1221-7. http://www.joponline.org/doi/abs/10.1902/jop.2000.72.9.1221?cookieSet=1&journalCode=jop
- Periodontal Therapy Lowers Levels of Heart Disease Inflammation Markers. [ Treating periodontal disease with scaling and root planing combined with a topical antibiotic gel can significantly lower the levels of two inflammatory proteins associated with a heightened risk of heart disease. People who have high levels of CRP in their blood are at high risk of heart disease. Results showed that in people who had elevated levels of CRP at baseline, removal of dental plaque bacteria by scaling or scaling combined with topical antibiotics produced a statistically significant reduction, bringing CRP levels close to the low-risk level.] Grossi, S, et al. SUNY Buffalo, ADA News 04/21/2004. http://www.ada.org/prof/resources/pubs/adanews/adanewsarticle.asp?articleid=841
- Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers. [Severe periodontitis is associated with elevated inflammatory markers in otherwise healthy populations. periodontitis seems to contribute to systemic inflammation. The potential significance of the reported findings relates to the magnitude of the observed decreases in CRP, the high prevalence of periodontitis in the population, and the fact that periodontitis can be treated.] D’Aiuto F., Parkar M, et al. http://jdr.iadrjournals.org/cgi/content/full/83/2/156
- Purification and characterization of a potent 70-kDa thiol lysyl- proteinase (Lys-gingivain) from Porphyromonas gingivalis that cleaves kininogens and fibrinogen. { These data suggest that lys- gingivain is a very potent proteinase that would be fully functional in anaerobic periodontal crevices and might participate in the pathogenesis of periodontitis.] http://www.jbc.org/cgi/content/abstract/268/11/7935
- Relationship Between Periodontal Disease and C-Reactive Protein Among Adults in the Atherosclerosis Risk in Communities Study. [Extensive periodontal disease and BMI are jointly associated with increased CRP levels in otherwise healthy, middle-aged adults, suggesting the need for medical and dental diagnoses when evaluating sources of acute-phase response in some patients. ] http://archinte.ama-assn.org/cgi/content/abstract/163/10/1172
- Relationship Between Periodontal Disease, Tooth Loss, and Carotid Artery Plaque. Stroke. 2003;34:2120. http://stroke.ahajournals.org/cgi/content/abstract/34/9/2120?etoc%20
- Short-term Effects of Intensive Periodontal Therapy on Serum Inflammatory Markers and Cholesterol. [Analysis of these data indicates that periodontitis causes moderate systemic inflammation in systemically healthy subjects.] D’Aiuto F., Nibali, L, et al http://jdr.iadrjournals.org/cgi/content/abstract/84/3/269
- Spokesman for the American Heart Association confirms the link between Perio and Heart Disease – Healthday News, November 29 2005- [“People who have chronic infections -- and gum disease is one of the major chronic infections -- are at increased risk later in life for atherosclerosis (hardening of the arteries) and coronary heart disease," said American Heart Association spokesman Dr. Richard Stein] http://health.yahoo.com/news/141399;_ylt=Ahq5pJAqH2GCLGes3r4j7NX3tMUF
- The antimicrobial treatment of periodontal disease: changing the treatment paradigm, Critical Reviews in Oral Biology & Medicine, Vol 10, 245-275. [This review highlights some of the evidence for the specific plaque hypothesis, and the questions that should be addressed if antimicrobial agents are to be used responsively and effectively.] http://crobm.iadrjournals.org/cgi/content/abstract/10/3/245
- The antimicrobial treatment of periodontal disease: changing the treatment paradigm http://crobm.iadrjournals.org/cgi/content/abstract/10/3/245
- Transmission of Porphyromonas gingivalis between spouses http://www.blackwell-synergy.com/doi/abs/10.1111/j.1600-051X.1993.tb00370.x
Alzheimer’s
- Inflammatory Markers and Cognition in well-functioning African-American and White Elders. [Serum markers of inflammation, especially IL-6 and CRP, are prospectively associated with cognitive decline in well-functioning elders. These findings support the hypothesis that inflammation contributes to cognitive decline in the elderly.] Yaffe, K, Lindquist K, et al. Neurology 2003;61:76-80. http://www.neurology.org/cgi/content/abstract/61/1/76
- Inflammation Linked to Cognitive Decline. J Neurology July 8, 2003 Yaffe, K, http://www.ncire.org/yaffe6.html
Cancer
Cardiovascular Disease
- Association between dental health and acute myocardial infarction. [Dental health was significantly worse in patients with acute myocardial infarction than in controls.] Brit Med J 189; 298:779-81.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2496855&dopt=Abstract
- Association between nanobacteria and periodontal disease. http://circ.ahajournals.org/cgi/content/full/108/8/e58
- Atherosclerosis — An Inflammatory Disease, Ross R, [Atherosclerosis is an inflammatory disease. [Inflammation and infection are factors that induce or promote inflammation and artherogenesis.] NEJM Vol.340:115-126 Jan 14, 1999 , http://content.nejm.org/cgi/content/short/340/2/115
- Coagulation and Thrombosis in Cardiovascular Disease: Plausible Contributions of Infectious Agents. [By initiating a procoagulant response, infectious agents can indirectly trigger a prothrombotic response. Alternatively, some microbes can directly trigger platelet aggregation in vitro and in animal models, suggesting direct prothrombotic potential in human cardiovascular disease. Activation of coagulation and thrombosis characterizes the pathological response to infectious agents in human disseminated intravascular coagulation and infective endocarditis. Given the underlying biological plausibility, the cumulative lifetime burden of chronic pathogens may be expected to create risk of atherosclerosis and thrombosis, and, indirectly, signs of cardiovascular disease.] Herzberg MC, Annals of Periodontology, 2001, Vol. 6, No. 1, Pages 16-19. http://www.joponline.org/doi/abs/10.1902/annals.2001.6.1.16
- Dental disease, fibrinogen and white cell count; links with myocardial infarction? [I nflammatory dental disease may be a determinant of fibrinogen level and white cell count in the general population, and that fibrinogen and white cell count may be two mediators of the link between dental disease and myocardial infarction.] Kweider M, Lowe GD, et. al, Scott med J. 1993 Jun;38(3):73-4. Department of Oral Surgery, Dental Hospital & School, Glasgow. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8356427&dopt=Abstract
- Dental Disease, Coronary Heart Disease and Stroke, and Inflammatory Markers. [In addition to "classical" risk factors for coronary heart disease (CHD) and stroke, "emerging" risk predictors (which may also play roles in pathogenesis) include measures of chronic infections and of chronic, low-grade activation of inflammation and of hemostasis. 1,2 As all dental healthcare professionals know (but probably fewer medical practitioners and their patients), the oral cavity is a major site of chronic infection and inflammation, particularly periodontal disease. In recent years there has been increasing interest in the "periodontal-systemic connection" between dental health parameters and the risks of cardiovascular disease, respiratory disease, diabetes mellitus, osteoporosis, and adverse pregnancy outcomes.] Lowe G, Circulation 2004;109:1076-1078.http://circ.ahajournals.org/cgi/content/full/109/9/1076 .
- Detection of Porphyromonas gingivalis DNA in Aortic Tissue by PCR. Stelzel M, Conrads G, et al. Journal of Periodontology, 2002, Vol. 73, No. 8, Pages 868-870. [These results might indicate a link between periodontopathogens entering the cardiovascular system and cardiovascular disease.] http://www.joponline.org/doi/abs/10.1902/jop.2002.73.8.868
- Early Carotid Atherosclerosis in Subjects With Periodontal Diseases. [The present results indicate that periodontal disease is associated with the development of early atherosclerotic carotid lesions.] Soder P, Soder B. Stroke. 2005;36:1195. http://stroke.ahajournals.org/cgi/content/full/36/6/1195
- Heart disease and stroke. http://www.perio.org/consumer/mbc.heart.htm
- Human athersclerotic plaque contains viable invasive actinobacillus actinomycetemcomitans and porphyromonas gingivalis, Arteriosclerosis. Kozarov et al, Human athersclerotic plaque contains viable invasive actinobacillus actinomycetemcomitans and porphyromonas gingivalis, Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:e17. http://atvb.ahajournals.org/cgi/reprint/25/3/e17?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&author1=kozarov&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=25&resourcetype=HWCIT
- Identification of periodontal pathogens in atheromatous plaques. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=
- Invasion of Aortic and Heart Endothelial Cells by Porphyromonas gingivalis http://intl-iai.asm.org/cgi/content/abstract/66/11/5337
- Live Oral Bacteria Found in Arterial Plaque, March 22, 2005 Ann Progulske-Fox, chief investigator, UofFL College of Dentistry. http://www.napa.ufl.edu/2005news/plaque.htm
- Microbiological Effects of Scaling and Root Planing. Haake SK, Isaacs D. http://www.dent.ucla.edu/pic/members/microscaling/
- New research finds link between gum disease, acute heart attacks, [ Heart attack survivors who suffer advanced gum disease show significantly higher levels of C-reactive protein in their blood than patients without gum disease, new University of North Carolina at Chapel Hill research indicates.] UNC News Services, http://www.unc.edu/news/archives/nov00/deliar111300.htm ; http://www.sciencedaily.com/releases/2000/11/001113071724.htm
- Pathogen-related oral spirochetes from dental plaque are invasive. Infect Immuno 59:3377-80, 1991. Riviere GR et al. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1894352&dopt=Abstract
- Periodontal Disease and Heart Health http://www.webmd.com/content/Article/104/107270.htm?printing=true
- Periodontal Disease and Risk of Cerebrovascular Disease Wu T, Trevisan M, et al. [Periodontal disease is an important risk factor for total CVA and, in particular, nonhemorrhagic stroke.] Arch Intern Med. 2000;160:2749-2755. http://archinte.ama-assn.org/cgi/content/abstract/160/18/2749
- Periodontal Disease May Increase Risk Of Stroke. [ People with periodontal disease are more likely to have thickened carotid arteries, which can lead to stroke, according to a study released at the American Academy of Neurology's 51st annual meeting in Toronto.] American Academy of Neurology 51 st annual meeting Toronto CA, 4/21/1999, Mitchell Elkind, MD, Columbia Univ, New York. http://www.pslgroup.com/dg/f896a.htm
- Periodontal infections and atherosclerosis: mere associations? [The influence of periodontitis on lipoprotein metabolism has emerged as a new, important factor. Recent studies provide experimental proof that periodontitis may predispose to atherosclerosis.] Pussien PJ et al. Current Opinion in Lipidology. 15(5):583-588, Oct 2004. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15361795&dopt=Abstract
- Relationship of Periodontal Disease to Carotid Artery Intima-Media Wall Thickness http://atvb.ahajournals.org/cgi/content/abstract/atvbaha;21/11/1816
- Role for Periodontal Bacteria in Cardiovascular Diseases. [ P. gingivalis exhibits several properties which could play a role in CVD as mediators of LDL oxidation, foam cell formation, and rupture of atherosclerotic plaque.] Kuramitsu HK, Annals of Periodontology, 2001, Vol. 6, No. 1, Pages 41-47. http://www.joponline.org/doi/abs/10.1902/annals.2001.6.1.41
- The Role of Inflammatory and Immunological Mediators in Periodontitis and Cardiovascular Disease. [Oral pathogens and inflammatory mediators (such as interleukin [IL]-1 and tumor necrosis factor [TNF]-α) from periodontal lesions intermittently reach the bloodstream inducing systemic inflammatory reactants such as acute-phase proteins, and immune effectors including systemic antibodies to periodontal bacteria.] DeNardin E, Annals of Periodontology, 2001, Vol. 6, No. 1, Pages 30-40. http://www.joponline.org/doi/abs/10.1902/annals.2001.6.1.30
- UC Davis researchers discover receptor pathway for C-reactive protein and its effects http://www.eurekalert.org/pub_releases/2005-06/uocd-udr062105.php
- UC Davis Study Identifies C-reactive Protein as Cause of Blood Clot Formation http://www.ucdmc.ucdavis.edu/news/CRP_study.html
- VCU Study Suggests New Link Between Severe Periodontitis and Cardiovascular Disease, RICHMOND, Va. (Dec. 1, 2005) – Virginia Commonwealth University researchers have found that changes in the plasma lipoprotein profile of patients with severe periodontitis – a condition characterized by chronic infection and inflammation of the gums - may contribute to these patients’ elevated risk for heart disease and stroke. http://www.vcu.edu/uns/Releases/2005/dec/120105.html
C-reactive Protein / Pro-inflammatory Mediators
- Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events. Ridker, PM, et.al., NEJM, Nov 14, 2002 Vol. 347:1557-1565 No 20. http://content.nejm.org/cgi/content/abstract/347/20/1557
- Comparison of C-reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events. [Data suggest that the C-reactive protein level is a stronger predictor of cardiovascular events than the LDL cholesterol level and that it adds prognostic information to that conveyed by the Framingham risk score.] Ridker PM , Rifai N, NEJM, Vol 347:1557-1565, Nov.14, 2002, No.20.http://content.nejm.org/cgi/content/abstract/347/20/1557
- C Reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. [The body's response to inflammation may play an important part in influencing the progression of atherosclerosis.] Mendall MA, Patel P, et. al. BMJ 1996;312:1061-1065 (27 April). http://bmj.bmjjournals.com/cgi/content/abstract/312/7038/1061
- C-Reactive Protein and LDL Cholesterol Levels in Women. [The authors concluded that increasing levels of C-reactive protein are an independent predictor of cardiovascular events and are even more strongly associated with cardiovascular risk than increased LDL cholesterol levels.] http://www.aafp.org/afp/20030315/tips/27.html
- C-Reactive Protein Increases Plasminogen Activator Inhibitor-1 Expression and Activity in Human Aortic Endothelial. Cells. American Heart Assoc Journal Circulation, 2003;107:398-404. Devaraj S et.al, Univ of California, Davis Medical Center. http://circ.ahajournals.org/cgi/content/abstract/107/3/398
- C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men. Koenig et al, Circulation. 1999;99:237-242. http://circ.ahajournals.org/cgi/content/abstract/circulationaha;99/2/237
- C-Reactive Protein, Subclinical Atherosclerosis, and Risk of Cardiovascular Events, Gavin J. Blake; Paul M. Ridker, http://atvb.ahajournals.org/cgi/content/full/22/10/1512
- Definition of Tumor necrosis factor http://www.medterms.com/script/main/art.asp?articlekey=25458
- Effect of treating Periodontitis on C-reactive protein levels: a pilot study, Mattila K, Vesanen M, et al, BMC Infectious Diseases 2002, 2:30. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=138813&rendertype=abstract
- Elevation of Systemic Markers Related to Cardiovascular Diseases in the Peripheral Blood of Periodontitis Patients http://www.joponline.org/doi/abs/10.1902/jop.2000.71.10.1528
- Heart attack survivors who suffer advanced gum disease show significantly higher levels of a protein in their blood called C-reactive protein (CRP) than such patients without gum disease, new University of North Carolina at Chapel Hill research indicates. http://www.unc.edu/news/archives/nov00/deliar111300.htm
- High-Sensitivity C-Reactive Protein Potential Adjunct for Global Risk Assessment in the Primary Prevention of Cardiovascular Disease [Inflammation plays a major role in atherothrombosis, and measurement of inflammatory markers such as HSCRP may provide a novel method for detecting individuals at high risk of plaque rupture.] Paul M. Ridker, MD, MPH http://circ.ahajournals.org/cgi/content/full/103/13/1813#F4
- High-Sensitivity C-Reactive Protein; Potential Adjunct for Global Risk Assessment in the Primary Prevention of Cardiovascular Disease http://circ.ahajournals.org/cgi/content/full/103/13/1813
- High-Sensitivity Serum C-Reactive Protein Levels in Subjects With or Without Myocardial Infarction or Periodontitis. Persson G., Pettersson T., et al, [As expected, elevated serum hsC-rp concentration and serum WBC counts are associated with acute coronary heart disease. (2) Elevated serum hsC-rp values are associated with radiographically defined periodontitis in subjects with no evidence of CVD.] J Clin Perio 32: 219–224, 2005.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15766362&dopt=Abstract
- Inflammation Marker Predicts Colon Cancer. Feb. 4, 2004 JAMA. [C-reactive protein, a marker of inflammation circulating in the blood already associated with increased risk of heart disease, can also be used to identify a person's risk of developing colon cancer, according to a Johns Hopkins study.] http://www.hopkinsmedicine.org/Press_releases/2004/02_10_04.html
- Joint Effects of C-Reactive Protein and Glycated Hemoglobin in Predicting Future Cardiovascular Events of Patients With Advanced Atherosclerosis. Schillinger et al, Circulation . 2003;108:2323. http://circ.ahajournals.org/cgi/content/abstract/108/19/2323
- Markers of Inflammation and Cardiovascular Disease. Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association [Basic science and epidemiological studies have developed an impressive case that atherogenesis is essentially an inflammatory response to a variety of risk factors and the consequences of this response lead to the development of acute coronary and cerebrovascular syndromes. … hs-CRP seems to add predictive value above that of currently established risk factors…. On the basis of the available evidence, the Writing Group recommends against screening of the entire adult population for hs-CRP as a public health measure.] http://circ.ahajournals.org/cgi/content/full/107/3/499
- Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease http://www.ingentaconnect.com/content/mksg/per/2003/00000038/00000002/art00015
- Periodontal Disease, C-Reactive Protein and Overall Health, http://www.perio.org/consumer/happy-heart.htm CRP levels are predictive of heart disease, and as a predictor for heart disease, is superior to and independent of cholesterol.
- Periodontal Treatment Reduces CRP and TNF-a, Iwamoto Y, Nishimura, F, et al, [Periodontal treatment is effective in reducting CRP and TNF- a value, mechanisms independent of adiponectin. Thus, the results indicate that periodontal inflammation up-regulate CRP and TNF- a, although still for the most part in the healty reference range. Elevated level of CRP and TNF- a might be associated with increased risk for future development of atherosclerosis in periodontal patients. ] http://iadr.confex.com/iadr/2003Goteborg/techprogram/abstract_30513.htm
- Population Distributions of C-reactive Protein in Apparently Healthy Men and Women in the United States: Implication for Clinical Interpretation. Nader Rifai1,2,a and Paul M. Ridker2,3. http://www.clinchem.org/cgi/content/full/49/4/666
- Production of interleukin-1 and tumor necrosis factor by human peripheral monocytes activated by periodontal bacteria and extracted lipopolysaccharides http://jdr.iadrjournals.org/cgi/content/abstract/67/8/1131
- Prospective Study of C-Reactive Protein, Homocysteine, and Plasma Lipid Levels as Predictors of Sudden Cardiac Death. [These results confirm the prognostic relevance of CRP, a sensitive systemic marker of inflammation, to the risk of CHD in a large, randomly selected cohort of initially healthy middle-aged men. They suggest that low-grade inflammation is involved in pathogenesis of atherosclerosis, especially its thrombo-occlusive complications.] http://circ.ahajournals.org/cgi/content/abstract/99/2/237
- Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental Periodontitis http://www.blackwell-synergy.com/links/doi/10.1034/j.1600-051x.2001.028003233.x/abs/
- Tumor Necrosis Factor http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?cmd=entry&id=191160
- Tumor necrosis factor http://en.wikipedia.org/wiki/Tumor_necrosis_factor
- Tumor necrosis factor by drdoc on-line http://www.arthritis.co.za/tnf.htm
- Vitamin C reduces level of C-reactive protein, finds UC Berkeley-led study http://www.eurekalert.org/pub_releases/2004-04/uoc--vcr041204.php
Diabetes
- [ Periodontal problems can complicate the management of diabetes, and uncontrolled diabetes may aggravate periodontal disease. Recent studies indicate that the majority of the U.S. population has some periodontal disease including the most common form, chronic adult periodontitis, formerly known as pyorrhea.] http://www.diabetesmonitor.com/b285.htm
- Bidirectional Interrelationships Between Diabetes and Periodontal Diseases: An Epidemiologic Perspective. [ The evidence reviewed supports viewing the relationship between diabetes and periodontal diseases as bidirectional.] Annals of Periodontology, 2001, Vol. 6, No. 1, Pages 99-112. Taylor G. http://www.joponline.org/doi/abs/10.1902/annals.2001.6.1.99
- Detection and prevention of periodontal disease in diabetes http://www.diabetesmonitor.com/b116.htm
- Oral Complications in Diabetes http://diabetes.niddk.nih.gov/dm/pubs/america/pdf/chapter23.pdf
- Periodontal Disease and Mortality in Type 2 Diabetes. [Periodontal disease may contribute to increased mortality associated with diabetes.] http://care.diabetesjournals.org/cgi/reprint/28/1/27?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=periodontal+disease&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT
- Periodontal Disease Predicts Mortality in Diabetics . Diabetes in Control.com:
- Diabetes Care 2005;28:27-32 National Institute of Diabetes and Digestive and Kidney Dieease, Phoenix, AZ. http://www.diabetesincontrol.com/modules.php?name=News&file=print&sid=2402
- Periodontal Disease Predicts Mortality in Diabetics. [Those with severe periodontal disease had a 28.4 % death rate and those with no or little periodontal disease had a 3.7% death rate.] http://www.defeatdiabetes.org/Articles/periodontal050124.htm
- Poorly controlled Type 2 diabetics twice as likely to develop periodontal disease. http://www.perio.org/consumer/mbc.diabetes.htm
- The Effect of Antimicrobial Periodontal Treatment on Circulating Tumor Necrosis Factor-Alpha and Glycated Hemoglobin Level in Patients With Type 2 Diabetes http://www.joponline.org/doi/abs/10.1902/jop.2001.72.6.774?journalCode=jop
- The Prevalence of Calcified Carotid Artery Atheromas on the Panoramic Radiographs of Patients with Type 2 Diabetes Mellitus. [Type 2 diabetes mellitus, which affects 15 Million Americans, is assocated with accelerated cervical carotid artery atherosclerosis and a heightened risk of stroke.] Friedlander AH, Maeder LA, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000:89:420-4. http://www.journals.elsevierhealth.com/periodicals/ymoe/article/PIIS1079210400701223/abstract?source=aemf
- The Severity of Periodontal Disease is Associated with the Development of Glucose Intolerance in Non-diabetics: The Hisayama Study. Dent Res 83(6):485-490,2004. http://jdr.iadrjournals.org/cgi/content/abstract/83/6/485?etoc
- Treatment of Periodontal Disease and Control of Diabetes: An Assessment of the Evidence and Need for Future Research . Annals of Periodontology 2001, Vol. 6, No. 1, Pages 138-145. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11887456&dopt=Citation ; http://www.joponline.org/doi/abs/10.1902/annals.2001.6.1.138
- Treatment of Periodontal Disease and control of diabetics : an assessment of evidence and need for future research. Grossi, SG Ann Periodontol. 2001 Dec 6 (1):138-45 . http://www.joponline.org/doi/abs/10.1902/annals.2001.6.1.138
- Treatment of Periodontal Disease in Diabetics Reduces Glycated Hemoglobin. J Periodontaol 1997;68:713-719, Sara Grossi, et.al, SUNY Buffalo http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9287060&dopt=Citation http://www.electronicipc.com/JournalEZ/detail.cfm?code=02250010680801
Kidney Disease
Lung Disease
Respiratory Diseases: [Scientists believe that through the aspiration process, bacteria cam cause frequent bouts of infection in patients with COPD.] http://www.perio.org/consumer/mbc.respiratory.htm
Obesity
- Elevation of serum C-reactive protein levels is associated with obesity in boys. Hypertens Res. 2003 Jul;26(7):541-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12924621&dopt=Abstract
- Obesity Is an Important Determinant of Baseline Serum C-Reactive Protein Concentration in Monozygotic Twins, Independent of Genetic Influences Circulation. 2004;109:3022-3028. http://circ.ahajournals.org/cgi/content/full/109/24/3022
- Periodontal disease, obesity associated with heart disease marker: study . Periodontal disease, obesity associated with heart disease marker: study, ADA News, 5/27/2003, citing Slade GD, Ghezzi EM, et al, Relationship Between Periodontal Disease and C-Reactive Protein Among Adults in the Atherosclerosis Risk in Communities Study, Arch Intern Med. 2003;163:1172-1179. http://www.ada.org/prof/resources/pubs/adanews/adanewsarticle.asp?articleid=270
Osteoporosis
- Inflammation Marker Predicts Colon Cancer. Feb. 4, 2004 JAMA. [C-reactive protein, a marker of inflammation circulating in the blood already associated with increased risk of heart disease, can also be used to identify a person's risk of developing colon cancer, according to a Johns Hopkins study.] http://www.hopkinsmedicine.org/Press_releases/2004/02_10_04.html
- Oral Cancer & Periodontal Disease. [ UB study links gum disease with oral cancer risk. O ral tumors were four times more prevalent and pre-cancerous lesions were twice as prevalent in people with periodontal disease (as assessed by clinical attachment loss) than in those without periodontal disease.] http://www.eurekalert.org/pub_releases/2003-03/uab-usl031303.php
- The Relationship Between Bone Mineral Density and Periodontitis in Postmenopausal Women. J Periodontology 2000, Vol. 71, No. 9, pp 1492-1498. http://www.joponline.org/doi/abs/10.1902/jop.2000.71.9.1492
- The Role of Osteopenia in Oral Bone Loss and Periodontal Disease. Wactawski-Wende J, Grossi SG, et.al, J Periodontol Vol 67 #10, Oct 1996. http://www.electronicipc.com/JournalEZ/detail.cfm?code=02250010671019
Pregnancy
- A review of premature birth and subclinical infection. Gibbs RS, Romero R, et al, A review of premature birth and subclinical infections. Am J Obstet Gynecol 166:1515-28, 1992. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=92280938
- Periodontal Disease and Preterm Birth: Results of a Pilot Intervention Study . [This trial indicates that performing SRP in pregnant women with periodontitis may reduce PTB in this population.] Jeffcoat, MK, Hauth JC, et al, J Periodontol 2003;74:1214-1218. http://www.joponline.org/doi/abs/10.1902/jop.2003.74.8.1214?prevSearch=allfield%3A%28Jeffcoat+Pregnant%29
- Periodontal Infection and Preterm Birth: Results of a Prospective Study . Jeffcoat MK, Geurs NC, et al. JADA 2001; 132:875-880. http://www.altcorp.com/AffinityLaboratory/pretermperio.htm
- Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol. 1996 Oct;67(10 Suppl):1103-13. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8910829&dopt=Abstract
- Periodontal Therapy May Reduce Incidence of Preterm Births http://www.perio.org/consumer/pregnancy-therapy.htm
- Periodontal Therapy May Reduce the Risk of Preterm Low Birth Weight in Women With Periodontal Disease: A randomized Controlled Trial. [ Pregnant women who receive treatment for their periodontal disease can reduce their risk of giving birth to a low birth-weight or pre- term baby . Of the women who received treatment during pregnancy, 2 percent gave birth to either a low birth-weight or pre-term infant. By comparison, 10 percent of the women who received treatment after birth had either a low birth-weight or pre-term baby.] Lopez NJ, et al. J Periodontology 2002, Vol. 73, No. 8, Pages 911-924. http://www.joponline.org/doi/abs/10.1902/jop.2002.73.8.911
- Periodontal Therapy Reduces the Rate of Preterm Low Birth Weight in Women With Pregnancy-Associated Gingivitis. Lopez NJ, Da Silva I et.al, J Periodontol 2005, Vol. 76,No.11-s:2144-2153. http://www.joponline.org/doi/abs/10.1902/jop.2005.76.11-S.2144?journalCode=jop
- Research Presented Today Provides Further Evidence on the Importance of Good Oral Health in Pregnant Women. American Academy of Periodontology Specialty Conference on Periodontal Medicine in Washington, DC, May 7, 2000 Marjorie Jeffcoat, DMD, Univ of Alabama Birmingham School of Dentistry. http://www.perio.org/consumer/women_risk.htm
- Study boosts suspected link between mothers’ gum disease and both premature birth, low birth weight. http://www.eurekalert.org/pub_releases/2002-03/uonc-sbs030502.php
Volatile Sulfur Compounds
- Effect of hydrogen sulfide and methyl mercaptan on the permeability of oral mucosa http://jdr.iadrjournals.org/cgi/content/abstract/63/7/994
- Efficacy of a Chlorine Dioxide-containing Mouthrinse in Oral Malodor , Frascella J. et al, TKL Research, Inc., Paramus, NJ, Journal of Dental Research, , (IADR Abstracts) 1999, p. 356, Article 2004. http://www.rowpar.com/professionals/oralhealth/research/5.html
- Management of Periodontitis with Oral Care Products, Chapek et al, Compendium Vol. XV No 6, 740-746, 1994. http://www.rowpar.com/professionals/oralhealth/research/6.html
- Reduction of Bleeding on Probing by Oral Care Products, Chapek et al, Compendium, Vol. 16, No. 2, 1995, 188-196.http://www.rowpar.com/professionals/oralhealth/research/7.html
- The Relationship Between Oral Malodor, Gingivitis, and Periodontitis. A Review. Ratcliff PA, Johnson PW J Periodontol. 1999 May;70(5):485-9 http://www.joponline.org/doi/abs/10.1902/jop.1999.70.5.485Ratcliff PA, Johnson PW. J Periodontol. 1999 May;70(5):485-9. Review.
- Volatile Sulfur Compounds and relation to Periodontal disease. http://dentalimplants-usa.com/Conditions/breath.html
- What is Chlorine Dioxide? http://www.lenntech.com/chlorine_dioxide.htm; http://www.epa.gov/pesticides/factsheets/chemicals/chlorinedioxidefactsheet.htm; http://www.clo2.com/
Laser Assisted Periodontal Therapy
- Advantages of a pulsed CO2 laser in direct pulp capping : a long-term in vivo study. [The CO2 laser seems to be a valuable aid in direct pulp capping; the efficiency of laser treatment can be increased by using a pulsed CO2 laser.] Moritz A, Schoop U, et al. Lasers Surg Med 1998;22(5):288-93 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&list_uids=9671995&cmd=Retrieve&dopt=Citation&indexed=google
- Effects of CO2 Laser Treatment on Fibroblast Attachment to Root Surfaces. A Scanning Electron Microscopy Analysis. [The group of specimens treated by laser and scaling showed the highest number of fibroblastic cells and a prevalence of well attached fibroblasts higher than control group and scaling/root planing group. The SEM observation didn't show any damages such as cracks and fissures of root surfaces treated by laser and scaling. These findings could suggest that CO 2 laser treatment could be considered as an adjunctive tool to detoxify and to condition the root surfaces in periodontal treatment. CO 2 laser treatment in defocused, pulsed mode with a low power of 2W combined with mechanical instrumentation constitutes a useful tool to condition the root surface and increase fibroblast attachment to root surfaces.] Crespi, R, Barone, A, et al, Journal of Periodontology 2002; 73, No.11 pp 1308-1312. http://www.joponline.org/doi/abs/10.1902/jop.2002.73.11.1308?journalCode=jop
- Laser Curretage when combined with SRP gives Superior results to SRP alone when measured by probing scores. ·LAPT when combined with SRP gives better healing and less patient discomfort than with SRP alone. Sulcular Debridement with Pulsed Nd: YAG" Lasers in Dentistry January 2002. http://www.millenniumdental.com/research/jan-02.html
- Laser de -epithelialization for enhanced guided tissue regeneration. A paradigm shift? Rossmann JA; Israel M. (Department of Periodontics, Baylor Collegeof Dentistry, Texas A&M University System Health Science Center at Dallas. Dent Clin North Am 2000 Oct;44(4):793-809 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11048272&dopt=Abstract
- Periodontal tissue regeneration in beagle dogs after laser therapy. [CO2 laser treatment of class III furcation induced formation of new periodontal ligament, cementum and bone.] Crespi R, Covani U, et al. Hospital S. Raffaele, Milan, Italy. Lasers Surg Med 1997;21(4):395-402 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9328987&dopt=Abstract
- The carbon dioxide laser as an aid in apicoectomy: an in vitro study. [CO2 laser treatment optimally prepares the tooth for final intraoperative filling because of sealing of the dentinal tubules, the resultant elimination of niches for bacteria and the sterilizing effect of the laser.] Moritz A, Gutknecht N, et al.J Clin Laser Med Surg 1997;15(4):185-8 .
- The CO2 laser as an aid in direct pulp capping . [The CO2 laser seems to be a valuable aid in direct pulp capping.] Moritz A, Schoop U, et al. J Endod 1998 Apr;24(4):248-51 . http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9641128&dopt=Abstract
- Use of the carbon dioxide laser in retarding epithelial migration : a pilot histological human study utilizing case reports. [ This is the first reported observation of human histologic evaluation using CO2 laser for de-epithelization and may warrant further study.] Israel M, ; Rossmann JA, et al. J Periodontol 1995 Mar;66(3):197-204. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7776164&dopt=Abstract
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Nutrition
Oral Hygiene Devices
- Comparison of the Hydrabrush Powered Toothbrush with Two Commercially-Available Powered Toothbrushes. Patters MR, Bland PS, et al. (Department of Periodontology and *Department of Pediatric Dentistry and Community Oral Health, University of Tennessee Health Science Center, College of Dentistry, Memphis, TN. Journal of the International Academy of Periodontology, July 2005 http://www.perioiap.org/absjul05.htm
- The effect of oral irrigation with a magnetic water treatment device on plaque and calculus. [The measurements of the group using an irrigator with a magnetic device showed a 44% greater reduction in calculus volume and a 42% greater reduction in area over the group using an unmagnetized irrigator. There appears to be a statistically significant difference in supragingival accretion volumes between conventional irrigation and using an irrigator with a magnetic water treatment device.] Watt DL, Rosenfelder C, et al. J Clin Periodontol 1993; 20: 3J4-317. http://www.hydrofloss.com/oral_health.htm#JOURNAL%20OF%20CLINICAL%20PERIODONTOLOGY
- The effectiveness of a magnetized water oral irrigator (Hydro Floss® ) on plaque, calculus and gingival health. [Irrigation with magnetized water resulted in 64% less calculus compared to the control group.] Johnson KE, Sanders JJ, et al, J Clin Periodontol 1998; 25: 316-321. http://www.hydrofloss.com/oral_health.htm#JOURNAL%20OF%20CLINICAL%20PERIODONTOLOGY